Israeli study: Pfizer vaccine does wear off after 6 months

Published in New England Journal of Medicine, prospective study of nearly 5,000 vaccinated healthcare workers supports decision to give booster shots.


The Pfizer-BioNTech Covid-19 vaccine. Photo by Abed Rahim Khatib/Flash90

Abigail Klein Leichman

(Israel21c) – The Pfizer-BioNTech vaccine against Covid-19 loses considerable effectiveness six months after the second dose, according to new Israeli research published in the New England Journal of Medicine.

The study echoes findings published by Pfizer and Kaiser Permanente in Lancet earlier in the week, showing the vaccine’s effectiveness drops from 88 to 47 percent after six months. This study also proved the vaccine 90% effective for at least six months at preventing hospitalization of infected people.

The Israeli study involved more than 4,800 fully vaccinated healthcare workers. From December 19, 2020, to July 9, 2021, their antibody response was tested monthly.

The researchers found a significant waning of immune responses — especially among men, people over 65 and immunosuppressed people.

“The decrease in neutralizing antibody titers was brisk initially, in the period of up to 70 to 80 days, but slowed thereafter,” they reported.

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The researched noted a “striking difference” between vaccinated people and recovered Covid-19 patients: “Overall, the accumulating evidence from our study and others show that long-term humoral [immune] response and vaccine effectiveness in previously infected persons is superior to that in recipients of two doses of vaccine.”

This may explain the substantially lower incidence of breakthrough infection among previously infected persons than among vaccinated persons.

Lead author Dr. Gili Regev Yochay, chief of infectious disease epidemiology at Sheba Medical Center, said the new study was one of three that contributed to the Israeli government’s world-first decision to give a third (booster) shot to citizens fully vaccinated at least five months before.

“We have shown in our previous work in the New England Journal of Medicine that there is a correlation between neutralizing antibodies and breakthrough infection,” she said.

The third study that influenced the decision to give boosters relied on Israeli Ministry of Health data indicating a decrease in vaccine effectiveness over six months.

The researchers also created a predictive model to assess the likelihood of different morbidity levels in various subpopulations. This could help health practitioners make decisions about specific patients.

Now, said Regev Yochay, Israeli and international scientists are working to quantify the threshold of antibodies required to protect from SARS-CoV-2 infection, from severe Covid-19, and from death due to Covid-19.

“After we learn the threshold of antibodies, the large table of probabilities we are publishing will help predict what is the right preventive measure for the different subpopulations,” she concluded in a statement to the press.